Synthesis, Characterization and Antifungal Activity of Some Substituted 4-thiazolidinone Derivatives
Hamdan Salameh Al-Ebaisat, Taher Sharif Ababne, Tareq Mousa Al Shboul, Taghreed M. Jazzazi
J. Pure App. Chem. Res. Vol 5, No 3 (2016), pp. 125-130
Submitted: March 09, 2016     Accepted: May 20, 2016     Published: September 05, 2016
DOI: http://dx.doi.org/10.21776/ub.jpacr.2016.005.03.248

Abstract


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A series of 4-thiazolidinone derivatives was prepared including 2- (4-phenyl)-3-(4-hydroxyphenyl)thiazolidinone-4-one (1), 2-(4-bromophenyl)-3-(4-hydroxy phenyl) thiazolidinone-4-one (2), 2-(4-chlorophenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (3), 2-(4-methylphenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (4),  2-(4-metoxyphenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (5), 2-(4-nitrophenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (6), 2,3-bis(4-hydroxyphenyl) thiazolidinone-4-one (7) and 2-(4-ethyl phenyl)-3-(4-hydroxyphenyl) thiazolidinone-4-one (8).   The chemical structures of prepared compounds have been characterized by Mass, IR, 1H-NMR, and elemental analyses. The biological activity of these compounds as fungicides was tested against three commercially known fungicides (C. albicans, patient isolate C. glabrata and C. krusei). The biological activity of compound (6) was found to be comparable to that of the commercially available fungicides.

Keywords : organic chemistry, medicinal chemistry
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